Iran under the Shah Ismail Safavi because of the ongoing internal and external wars, lack of efficient politic-bureaucratic measures and various other cusses was distracted and economically slack. The chaos continued in the period of his successor, Shah Tahmasp. Necessary requirements for the development of Guilds and craftsmen wasn’t prepared During the first ten years of his rule, but following the peace between Shah Tahmasp and ottomans, situation changed, and the economy revived. But this situation didn’t last long, king’s greed and his neglect over the people and society again brought the country into turmoil and crisis, and meantime the greatest harm occurred to the economy and especially the guilds, and one of its results was the discontent and protest of people, mostly because of economic matters and embodied in the Tabriz uprising of 981 A.D. The purpose of this study was to evaluate the situation guilds at the time of shah Tahmasp and its impact on the economy of the country.